Physostol
Brand names,
Physostol
Analogs
Physostol
Brand Names Mixture
Physostol
Chemical_Formula
C15H21N3O2
Physostol
RX_link
http://www.rxlist.com/cgi/generic3/physostigmine.htm
Physostol
fda sheet
Physostol
msds (material safety sheet)
Physostol
Synthesis Reference
Zhang J,et al. Appl Microbiol Biotechnol. 44(5):568-75.
Physostol
Molecular Weight
275.346 g/mol
Physostol
Melting Point
105.5 oC
Physostol
H2O Solubility
7760 mg/L
Physostol
State
Solid
Physostol
LogP
1.582
Physostol
Dosage Forms
Liquid
Physostol
Indication
For the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.
Physostol
Pharmacology
Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma. Because it crosses the blood-brain barrier, it is also used to treat the central nervous system effects of atropine overdose and other anticholinergic drug overdoses. Physostigmine can reverse both central and peripheral anticholinergia.
Physostol
Absorption
No information avaliable
Physostol
side effects and Toxicity
Side effects include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth, blurred vision or change in near or distant vision, and eye pain.
Physostol
Patient Information
No information avaliable
Physostol
Organisms Affected
Humans and other mammals