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Procainamide Brand names, Procainamide Analogs

Procainamide Brand Names Mixture

  • No information avaliable

Procainamide Chemical_Formula


Procainamide RX_link

Procainamide fda sheet

Procainamide msds (material safety sheet)

Procainamide MSDS

Procainamide Synthesis Reference

Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8

Procainamide Molecular Weight

235.325 g/mol

Procainamide Melting Point

165-169 oC

Procainamide H2O Solubility

5050 mg/L

Procainamide State


Procainamide LogP


Procainamide Dosage Forms

Capsule; Liquid; Solution; Tablet (extended-release)

Procainamide Indication

For the treatment of life-threatening ventricular arrhythmias.

Procainamide Pharmacology

Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Procainamide Absorption

75 to 95%

Procainamide side effects and Toxicity

LD50=95 mg/kg (rat, IV); LD50=312 mg/kg (mouse, oral); LD50=103 mg/kg (mouse, IV); LD50=250 mg/kg (rabbit, IV)

Procainamide Patient Information

The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.

The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.

Procainamide Organisms Affected

Humans and other mammals