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Procain Brand names, Procain Analogs

Procain Brand Names Mixture

  • No information avaliable

Procain Chemical_Formula


Procain RX_link

Procain fda sheet

Procain msds (material safety sheet)

Procain MSDS

Procain Synthesis Reference

Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8

Procain Molecular Weight

235.325 g/mol

Procain Melting Point

165-169 oC

Procain H2O Solubility

5050 mg/L

Procain State


Procain LogP


Procain Dosage Forms

Capsule; Liquid; Solution; Tablet (extended-release)

Procain Indication

For the treatment of life-threatening ventricular arrhythmias.

Procain Pharmacology

Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Procain Absorption

75 to 95%

Procain side effects and Toxicity

LD50=95 mg/kg (rat, IV); LD50=312 mg/kg (mouse, oral); LD50=103 mg/kg (mouse, IV); LD50=250 mg/kg (rabbit, IV)

Procain Patient Information

The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.

The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.

Procain Organisms Affected

Humans and other mammals