Lotrel
Lotrel Brand names, Lotrel Analogs
Lotrel Brand Names Mixture
- Lotrel (amlodipine + benazepril)
Lotrel Chemical_Formula
C20H25ClN2O5
Lotrel RX_link
http://www.rxlist.com/cgi/generic/amlod2.htm
Lotrel fda sheet
Lotrel msds (material safety sheet)
Lotrel Synthesis Reference
S. F. Campbell et al., U.S. Pat. 4,572,909 (1986)
Lotrel Molecular Weight
408.876 g/mol
Lotrel Melting Point
178-179oC
Lotrel H2O Solubility
75.3 mg/L
Lotrel State
Solid
Lotrel LogP
2.347
Lotrel Dosage Forms
Tablets (equivalent to 2.5, 5 and 10 mg)
Lotrel Indication
For the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Lotrel Pharmacology
Amlodipine, a calcium-channel blocker, is used alone or with benazepril, an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Amlodipine is similar to the peripheral vasodilator nifedipine and other members of the dihydropyridine class.
Lotrel Absorption
Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract.
Lotrel side effects and Toxicity
Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.
Lotrel Patient Information
Lotrel Organisms Affected
Humans and other mammals
