Lipinox
Lipinox Brand names, Lipinox Analogs
Lipinox Brand Names Mixture
- Lotrel (amlodipine + benazepril)
Lipinox Chemical_Formula
C20H25ClN2O5
Lipinox RX_link
http://www.rxlist.com/cgi/generic/amlod2.htm
Lipinox fda sheet
Lipinox msds (material safety sheet)
Lipinox Synthesis Reference
S. F. Campbell et al., U.S. Pat. 4,572,909 (1986)
Lipinox Molecular Weight
408.876 g/mol
Lipinox Melting Point
178-179oC
Lipinox H2O Solubility
75.3 mg/L
Lipinox State
Solid
Lipinox LogP
2.347
Lipinox Dosage Forms
Tablets (equivalent to 2.5, 5 and 10 mg)
Lipinox Indication
For the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Lipinox Pharmacology
Amlodipine, a calcium-channel blocker, is used alone or with benazepril, an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Amlodipine is similar to the peripheral vasodilator nifedipine and other members of the dihydropyridine class.
Lipinox Absorption
Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract.
Lipinox side effects and Toxicity
Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.
Lipinox Patient Information
Lipinox Organisms Affected
Humans and other mammals
