Amlodipine Benzenesulfonate
Brand names,
Amlodipine Benzenesulfonate
Analogs
Amlodipine Benzenesulfonate
Brand Names Mixture
- Lotrel (amlodipine + benazepril)
Amlodipine Benzenesulfonate
Chemical_Formula
C20H25ClN2O5
Amlodipine Benzenesulfonate
RX_link
http://www.rxlist.com/cgi/generic/amlod2.htm
Amlodipine Benzenesulfonate
fda sheet
Amlodipine Benzenesulfonate
msds (material safety sheet)
Amlodipine Benzenesulfonate
Synthesis Reference
S. F. Campbell et al., U.S. Pat. 4,572,909 (1986)
Amlodipine Benzenesulfonate
Molecular Weight
408.876 g/mol
Amlodipine Benzenesulfonate
Melting Point
178-179oC
Amlodipine Benzenesulfonate
H2O Solubility
75.3 mg/L
Amlodipine Benzenesulfonate
State
Solid
Amlodipine Benzenesulfonate
LogP
2.347
Amlodipine Benzenesulfonate
Dosage Forms
Tablets (equivalent to 2.5, 5 and 10 mg)
Amlodipine Benzenesulfonate
Indication
For the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Amlodipine Benzenesulfonate
Pharmacology
Amlodipine, a calcium-channel blocker, is used alone or with benazepril, an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Amlodipine is similar to the peripheral vasodilator nifedipine and other members of the dihydropyridine class.
Amlodipine Benzenesulfonate
Absorption
Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract.
Amlodipine Benzenesulfonate
side effects and Toxicity
Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.
Amlodipine Benzenesulfonate
Patient Information
Amlodipine Benzenesulfonate
Organisms Affected
Humans and other mammals