Amlodipine Besylate
Brand names,
Amlodipine Besylate
Analogs
Amlodipine Besylate
Brand Names Mixture
- Lotrel (amlodipine + benazepril)
Amlodipine Besylate
Chemical_Formula
C20H25ClN2O5
Amlodipine Besylate
RX_link
http://www.rxlist.com/cgi/generic/amlod2.htm
Amlodipine Besylate
fda sheet
Amlodipine Besylate
msds (material safety sheet)
Amlodipine Besylate
Synthesis Reference
S. F. Campbell et al., U.S. Pat. 4,572,909 (1986)
Amlodipine Besylate
Molecular Weight
408.876 g/mol
Amlodipine Besylate
Melting Point
178-179oC
Amlodipine Besylate
H2O Solubility
75.3 mg/L
Amlodipine Besylate
State
Solid
Amlodipine Besylate
LogP
2.347
Amlodipine Besylate
Dosage Forms
Tablets (equivalent to 2.5, 5 and 10 mg)
Amlodipine Besylate
Indication
For the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Amlodipine Besylate
Pharmacology
Amlodipine, a calcium-channel blocker, is used alone or with benazepril, an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Amlodipine is similar to the peripheral vasodilator nifedipine and other members of the dihydropyridine class.
Amlodipine Besylate
Absorption
Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract.
Amlodipine Besylate
side effects and Toxicity
Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.
Amlodipine Besylate
Patient Information
Amlodipine Besylate
Organisms Affected
Humans and other mammals