Amlocard
Brand names,
Amlocard
Analogs
Amlocard
Brand Names Mixture
- Lotrel (amlodipine + benazepril)
Amlocard
Chemical_Formula
C20H25ClN2O5
Amlocard
RX_link
http://www.rxlist.com/cgi/generic/amlod2.htm
Amlocard
fda sheet
Amlocard
msds (material safety sheet)
Amlocard
Synthesis Reference
S. F. Campbell et al., U.S. Pat. 4,572,909 (1986)
Amlocard
Molecular Weight
408.876 g/mol
Amlocard
Melting Point
178-179oC
Amlocard
H2O Solubility
75.3 mg/L
Amlocard
State
Solid
Amlocard
LogP
2.347
Amlocard
Dosage Forms
Tablets (equivalent to 2.5, 5 and 10 mg)
Amlocard
Indication
For the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Amlocard
Pharmacology
Amlodipine, a calcium-channel blocker, is used alone or with benazepril, an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Amlodipine is similar to the peripheral vasodilator nifedipine and other members of the dihydropyridine class.
Amlocard
Absorption
Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract.
Amlocard
side effects and Toxicity
Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.
Amlocard
Patient Information
Amlocard
Organisms Affected
Humans and other mammals