Histazol
Brand names,
Histazol
Analogs
Histazol
Brand Names Mixture
Histazol
Chemical_Formula
C28H31FN4O
Histazol
RX_link
http://www.rxlist.com/cgi/generic/astem.htm
Histazol
fda sheet
Histazol
msds (material safety sheet)
Histazol
Synthesis Reference
F. Janssens et al., U.S. Pat. 4,219,559 (1980)
Histazol
Molecular Weight
458.571 g/mol
Histazol
Melting Point
149.1oC
Histazol
H2O Solubility
432 mg/L
Histazol
State
Solid
Histazol
LogP
5.572
Histazol
Dosage Forms
Suspension; Tablet
Histazol
Indication
For the relief of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria.
Histazol
Pharmacology
Astemizole, an H1-receptor antagonist, is similar in structure to terfenadine and haloperidol, a butyrophenone antipsychotic. It has anticholinergic (atropine-like) and antipruritic effects.
Histazol
Absorption
Rapidly absorbed from the gastrointestinal tract.
Histazol
side effects and Toxicity
LD50=2052mg/kg in mice
Histazol
Patient Information
Histazol
Organisms Affected
Humans and other mammals