Hismanal
Brand names,
Hismanal
Analogs
Hismanal
Brand Names Mixture
Hismanal
Chemical_Formula
C28H31FN4O
Hismanal
RX_link
http://www.rxlist.com/cgi/generic/astem.htm
Hismanal
fda sheet
Hismanal
msds (material safety sheet)
Hismanal
Synthesis Reference
F. Janssens et al., U.S. Pat. 4,219,559 (1980)
Hismanal
Molecular Weight
458.571 g/mol
Hismanal
Melting Point
149.1oC
Hismanal
H2O Solubility
432 mg/L
Hismanal
State
Solid
Hismanal
LogP
5.572
Hismanal
Dosage Forms
Suspension; Tablet
Hismanal
Indication
For the relief of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria.
Hismanal
Pharmacology
Astemizole, an H1-receptor antagonist, is similar in structure to terfenadine and haloperidol, a butyrophenone antipsychotic. It has anticholinergic (atropine-like) and antipruritic effects.
Hismanal
Absorption
Rapidly absorbed from the gastrointestinal tract.
Hismanal
side effects and Toxicity
LD50=2052mg/kg in mice
Hismanal
Patient Information
Hismanal
Organisms Affected
Humans and other mammals