Astemisol
Brand names,
Astemisol
Analogs
Astemisol
Brand Names Mixture
Astemisol
Chemical_Formula
C28H31FN4O
Astemisol
RX_link
http://www.rxlist.com/cgi/generic/astem.htm
Astemisol
fda sheet
Astemisol
msds (material safety sheet)
Astemisol
Synthesis Reference
F. Janssens et al., U.S. Pat. 4,219,559 (1980)
Astemisol
Molecular Weight
458.571 g/mol
Astemisol
Melting Point
149.1oC
Astemisol
H2O Solubility
432 mg/L
Astemisol
State
Solid
Astemisol
LogP
5.572
Astemisol
Dosage Forms
Suspension; Tablet
Astemisol
Indication
For the relief of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria.
Astemisol
Pharmacology
Astemizole, an H1-receptor antagonist, is similar in structure to terfenadine and haloperidol, a butyrophenone antipsychotic. It has anticholinergic (atropine-like) and antipruritic effects.
Astemisol
Absorption
Rapidly absorbed from the gastrointestinal tract.
Astemisol
side effects and Toxicity
LD50=2052mg/kg in mice
Astemisol
Patient Information
Astemisol
Organisms Affected
Humans and other mammals