Astemisan
Brand names,
Astemisan
Analogs
Astemisan
Brand Names Mixture
Astemisan
Chemical_Formula
C28H31FN4O
Astemisan
RX_link
http://www.rxlist.com/cgi/generic/astem.htm
Astemisan
fda sheet
Astemisan
msds (material safety sheet)
Astemisan
Synthesis Reference
F. Janssens et al., U.S. Pat. 4,219,559 (1980)
Astemisan
Molecular Weight
458.571 g/mol
Astemisan
Melting Point
149.1oC
Astemisan
H2O Solubility
432 mg/L
Astemisan
State
Solid
Astemisan
LogP
5.572
Astemisan
Dosage Forms
Suspension; Tablet
Astemisan
Indication
For the relief of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria.
Astemisan
Pharmacology
Astemizole, an H1-receptor antagonist, is similar in structure to terfenadine and haloperidol, a butyrophenone antipsychotic. It has anticholinergic (atropine-like) and antipruritic effects.
Astemisan
Absorption
Rapidly absorbed from the gastrointestinal tract.
Astemisan
side effects and Toxicity
LD50=2052mg/kg in mice
Astemisan
Patient Information
Astemisan
Organisms Affected
Humans and other mammals