Chlorthalidone

Chlorthalidone Brand names, Chlorthalidone Analogs

Chlorthalidone Brand Names Mixture

Tenoretic (chlorthalidone + atenolol)

Chlorthalidone Chemical_Formula

C₁₄H₁₁ClN₂O₄S

Chlorthalidone RX_link

http://www.rxlist.com/cgi/generic3/chlorthalidone.htm

Chlorthalidone fda sheet

Chlorthalidone msds (material safety sheet)

Chlorthalidone Synthesis Reference

Graf et al.; Helv. Chem.; Acta 42; 1085 (1959); U.S.Pat.3,055,904 (1962)

Chlorthalidone Molecular Weight

338.767 g/mol

Chlorthalidone Melting Point

218-264^oC

Chlorthalidone H₂O Solubility

120 mg/L

Chlorthalidone State

Solid

Chlorthalidone LogP

1.718

Chlorthalidone Dosage Forms

Tablet

Chlorthalidone Indication

For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Chlorthalidone Pharmacology

Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.

Chlorthalidone Absorption

Absorbed relatively rapidly after oral administration.

Chlorthalidone side effects and Toxicity

Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.

Chlorthalidone Patient Information

Patients should inform their physician if they have: (1) had an allergic reaction to chlorthalidone or other diuretics or have asthma, (2) kidney disease, (3) liver disease, (4) gout, (5) systemic lupus erythematosus, or (6) been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.

Patients should be cautioned to contact their physician if they experience any of the following symptoms of potassium loss: excess thirst, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or increased heart rate or pulse.

Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring.

Chlorthalidone Organisms Affected

Humans and other mammals