Chlorphthalidolone

Chlorphthalidolone Brand names, Chlorphthalidolone Analogs

Chlorphthalidolone Brand Names Mixture

Tenoretic (chlorthalidone + atenolol)

Chlorphthalidolone Chemical_Formula

C₁₄H₁₁ClN₂O₄S

Chlorphthalidolone RX_link

http://www.rxlist.com/cgi/generic3/chlorthalidone.htm

Chlorphthalidolone fda sheet

Chlorphthalidolone msds (material safety sheet)

Chlorphthalidolone Synthesis Reference

Graf et al.; Helv. Chem.; Acta 42; 1085 (1959); U.S.Pat.3,055,904 (1962)

Chlorphthalidolone Molecular Weight

338.767 g/mol

Chlorphthalidolone Melting Point

218-264^oC

Chlorphthalidolone H₂O Solubility

120 mg/L

Chlorphthalidolone State

Solid

Chlorphthalidolone LogP

1.718

Chlorphthalidolone Dosage Forms

Tablet

Chlorphthalidolone Indication

For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Chlorphthalidolone Pharmacology

Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.

Chlorphthalidolone Absorption

Absorbed relatively rapidly after oral administration.

Chlorphthalidolone side effects and Toxicity

Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.

Chlorphthalidolone Patient Information

Patients should inform their physician if they have: (1) had an allergic reaction to chlorthalidone or other diuretics or have asthma, (2) kidney disease, (3) liver disease, (4) gout, (5) systemic lupus erythematosus, or (6) been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.

Patients should be cautioned to contact their physician if they experience any of the following symptoms of potassium loss: excess thirst, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or increased heart rate or pulse.

Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring.

Chlorphthalidolone Organisms Affected

Humans and other mammals