Chlorphthalidolone

• Diuretics
• Antihypertensive Agents
• ATC:C03BA

• Chlorothalidone
• Chlorphthalidolone
• Chlorphthalidone
• Chlortalidone
• Chlorthalidon
• Clodronic Acid
• Higroton
• Hydro-Long
• Hygroton
• Igroton
• Isoren
• Natriuran
• Oradil
• Phthalamodine
• Phthalamudine
• Renon
• Saluretin
• Tenoretic
• Thalitone
• Zambesil

• Tenoretic (chlorthalidone + atenolol)

C₁₄H₁₁ClN₂O₄S

http://www.rxlist.com/cgi/generic3/chlorthalidone.htm

Graf et al.; Helv. Chem.; Acta 42; 1085 (1959); U.S.Pat.3,055,904 (1962)

338.767 g/mol

218-264^oC

120 mg/L

Solid

1.718

Tablet

For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.

Absorbed relatively rapidly after oral administration.

Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.

Patients should inform their physician if they have: (1) had an allergic reaction to chlorthalidone or other diuretics or have asthma, (2) kidney disease, (3) liver disease, (4) gout, (5) systemic lupus erythematosus, or (6) been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.

Patients should be cautioned to contact their physician if they experience any of the following symptoms of potassium loss: excess thirst, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or increased heart rate or pulse.

Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring.

Humans and other mammals