Clodronic Acid
Clodronic Acid Brand names, Clodronic Acid Analogs
Clodronic Acid Brand Names Mixture
- Tenoretic (chlorthalidone + atenolol)
Clodronic Acid Chemical_Formula
C14H11ClN2O4S
Clodronic Acid RX_link
http://www.rxlist.com/cgi/generic3/chlorthalidone.htm
Clodronic Acid fda sheet
Clodronic Acid msds (material safety sheet)
Clodronic Acid Synthesis Reference
Graf et al.; Helv. Chem.; Acta 42; 1085 (1959); U.S.Pat.3,055,904 (1962)
Clodronic Acid Molecular Weight
338.767 g/mol
Clodronic Acid Melting Point
218-264oC
Clodronic Acid H2O Solubility
120 mg/L
Clodronic Acid State
Solid
Clodronic Acid LogP
1.718
Clodronic Acid Dosage Forms
Tablet
Clodronic Acid Indication
For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Clodronic Acid Pharmacology
Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.
Clodronic Acid Absorption
Absorbed relatively rapidly after oral administration.
Clodronic Acid side effects and Toxicity
Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.
Clodronic Acid Patient Information
Patients should inform their physician if they have: (1) had an allergic reaction to chlorthalidone or other diuretics or have asthma, (2) kidney disease, (3) liver disease, (4) gout, (5) systemic lupus erythematosus, or (6) been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.
Patients should be cautioned to contact their physician if they experience any of the following symptoms of potassium loss: excess thirst, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or increased heart rate or pulse.
Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring.
Clodronic Acid Organisms Affected
Humans and other mammals
