Chlorphthalidone
Brand names,
Chlorphthalidone
Analogs
Chlorphthalidone
Brand Names Mixture
- Tenoretic (chlorthalidone + atenolol)
Chlorphthalidone
Chemical_Formula
C14H11ClN2O4S
Chlorphthalidone
RX_link
http://www.rxlist.com/cgi/generic3/chlorthalidone.htm
Chlorphthalidone
fda sheet
Chlorphthalidone
msds (material safety sheet)
Chlorphthalidone
Synthesis Reference
Graf et al.; Helv. Chem.; Acta 42; 1085 (1959); U.S.Pat.3,055,904 (1962)
Chlorphthalidone
Molecular Weight
338.767 g/mol
Chlorphthalidone
Melting Point
218-264oC
Chlorphthalidone
H2O Solubility
120 mg/L
Chlorphthalidone
State
Solid
Chlorphthalidone
LogP
1.718
Chlorphthalidone
Dosage Forms
Tablet
Chlorphthalidone
Indication
For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Chlorphthalidone
Pharmacology
Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.
Chlorphthalidone
Absorption
Absorbed relatively rapidly after oral administration.
Chlorphthalidone
side effects and Toxicity
Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.
Chlorphthalidone
Patient Information
Patients should inform their physician if they have: (1) had an allergic reaction to chlorthalidone or other
diuretics or have asthma, (2) kidney disease, (3) liver disease, (4) gout, (5) systemic lupus erythematosus, or (6)
been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.
Patients should be cautioned to contact their physician if they experience any of the following symptoms of
potassium loss: excess thirst, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or
increased heart rate or pulse.
Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring.
Chlorphthalidone
Organisms Affected
Humans and other mammals