Chlorothalidone

Chlorothalidone Brand names, Chlorothalidone Analogs

Chlorothalidone Brand Names Mixture

Tenoretic (chlorthalidone + atenolol)

Chlorothalidone Chemical_Formula

C₁₄H₁₁ClN₂O₄S

Chlorothalidone RX_link

http://www.rxlist.com/cgi/generic3/chlorthalidone.htm

Chlorothalidone fda sheet

Chlorothalidone msds (material safety sheet)

Chlorothalidone Synthesis Reference

Graf et al.; Helv. Chem.; Acta 42; 1085 (1959); U.S.Pat.3,055,904 (1962)

Chlorothalidone Molecular Weight

338.767 g/mol

Chlorothalidone Melting Point

218-264^oC

Chlorothalidone H₂O Solubility

120 mg/L

Chlorothalidone State

Solid

Chlorothalidone LogP

1.718

Chlorothalidone Dosage Forms

Tablet

Chlorothalidone Indication

For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Chlorothalidone Pharmacology

Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.

Chlorothalidone Absorption

Absorbed relatively rapidly after oral administration.

Chlorothalidone side effects and Toxicity

Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.

Chlorothalidone Patient Information

Patients should inform their physician if they have: (1) had an allergic reaction to chlorthalidone or other diuretics or have asthma, (2) kidney disease, (3) liver disease, (4) gout, (5) systemic lupus erythematosus, or (6) been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.

Patients should be cautioned to contact their physician if they experience any of the following symptoms of potassium loss: excess thirst, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or increased heart rate or pulse.

Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring.

Chlorothalidone Organisms Affected

Humans and other mammals