Tenoretic
Brand names,
Tenoretic
Analogs
Tenoretic
Brand Names Mixture
- Tenoretic (chlorthalidone + atenolol)
Tenoretic
Chemical_Formula
C14H11ClN2O4S
Tenoretic
RX_link
http://www.rxlist.com/cgi/generic3/chlorthalidone.htm
Tenoretic
fda sheet
Tenoretic
msds (material safety sheet)
Tenoretic
Synthesis Reference
Graf et al.; Helv. Chem.; Acta 42; 1085 (1959); U.S.Pat.3,055,904 (1962)
Tenoretic
Molecular Weight
338.767 g/mol
Tenoretic
Melting Point
218-264oC
Tenoretic
H2O Solubility
120 mg/L
Tenoretic
State
Solid
Tenoretic
LogP
1.718
Tenoretic
Dosage Forms
Tablet
Tenoretic
Indication
For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Tenoretic
Pharmacology
Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.
Tenoretic
Absorption
Absorbed relatively rapidly after oral administration.
Tenoretic
side effects and Toxicity
Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.
Tenoretic
Patient Information
Patients should inform their physician if they have: (1) had an allergic reaction to chlorthalidone or other
diuretics or have asthma, (2) kidney disease, (3) liver disease, (4) gout, (5) systemic lupus erythematosus, or (6)
been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.
Patients should be cautioned to contact their physician if they experience any of the following symptoms of
potassium loss: excess thirst, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or
increased heart rate or pulse.
Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring.
Tenoretic
Organisms Affected
Humans and other mammals