Alti-Acyclovir
Alti-Acyclovir Brand names, Alti-Acyclovir Analogs
Alti-Acyclovir Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
Alti-Acyclovir Chemical_Formula
C8H11N5O3
Alti-Acyclovir RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
Alti-Acyclovir fda sheet
Alti-Acyclovir msds (material safety sheet)
Alti-Acyclovir Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
Alti-Acyclovir Molecular Weight
225.205 g/mol
Alti-Acyclovir Melting Point
256.5 - 257 oC
Alti-Acyclovir H2O Solubility
3.399 mg/L
Alti-Acyclovir State
Solid
Alti-Acyclovir LogP
-1.314
Alti-Acyclovir Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
Alti-Acyclovir Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Alti-Acyclovir Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Alti-Acyclovir Absorption
Oral: bioavailability 10 to 20%
Alti-Acyclovir side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
Alti-Acyclovir Patient Information
Alti-Acyclovir Organisms Affected
Human herpes virus
