Aciclovir
Aciclovir Brand names, Aciclovir Analogs
Aciclovir Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
Aciclovir Chemical_Formula
C8H11N5O3
Aciclovir RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
Aciclovir fda sheet
Aciclovir msds (material safety sheet)
Aciclovir Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
Aciclovir Molecular Weight
225.205 g/mol
Aciclovir Melting Point
256.5 - 257 oC
Aciclovir H2O Solubility
3.399 mg/L
Aciclovir State
Solid
Aciclovir LogP
-1.314
Aciclovir Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
Aciclovir Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Aciclovir Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Aciclovir Absorption
Oral: bioavailability 10 to 20%
Aciclovir side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
Aciclovir Patient Information
Aciclovir Organisms Affected
Human herpes virus
