Wellcome-248u
Wellcome-248u Brand names, Wellcome-248u Analogs
Wellcome-248u Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
Wellcome-248u Chemical_Formula
C8H11N5O3
Wellcome-248u RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
Wellcome-248u fda sheet
Wellcome-248u msds (material safety sheet)
Wellcome-248u Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
Wellcome-248u Molecular Weight
225.205 g/mol
Wellcome-248u Melting Point
256.5 - 257 oC
Wellcome-248u H2O Solubility
3.399 mg/L
Wellcome-248u State
Solid
Wellcome-248u LogP
-1.314
Wellcome-248u Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
Wellcome-248u Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Wellcome-248u Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Wellcome-248u Absorption
Oral: bioavailability 10 to 20%
Wellcome-248u side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
Wellcome-248u Patient Information
Wellcome-248u Organisms Affected
Human herpes virus
