Aciclovier
Aciclovier Brand names, Aciclovier Analogs
Aciclovier Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
Aciclovier Chemical_Formula
C8H11N5O3
Aciclovier RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
Aciclovier fda sheet
Aciclovier msds (material safety sheet)
Aciclovier Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
Aciclovier Molecular Weight
225.205 g/mol
Aciclovier Melting Point
256.5 - 257 oC
Aciclovier H2O Solubility
3.399 mg/L
Aciclovier State
Solid
Aciclovier LogP
-1.314
Aciclovier Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
Aciclovier Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Aciclovier Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Aciclovier Absorption
Oral: bioavailability 10 to 20%
Aciclovier side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
Aciclovier Patient Information
Aciclovier Organisms Affected
Human herpes virus
