AC2
AC2 Brand names, AC2 Analogs
AC2 Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
AC2 Chemical_Formula
C8H11N5O3
AC2 RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
AC2 fda sheet
AC2 msds (material safety sheet)
AC2 Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
AC2 Molecular Weight
225.205 g/mol
AC2 Melting Point
256.5 - 257 oC
AC2 H2O Solubility
3.399 mg/L
AC2 State
Solid
AC2 LogP
-1.314
AC2 Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
AC2 Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
AC2 Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
AC2 Absorption
Oral: bioavailability 10 to 20%
AC2 side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
AC2 Patient Information
AC2 Organisms Affected
Human herpes virus
