Zovirax Wellstat Pac
Brand names,
Zovirax Wellstat Pac
Analogs
Zovirax Wellstat Pac
Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
Zovirax Wellstat Pac
Chemical_Formula
C8H11N5O3
Zovirax Wellstat Pac
RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
Zovirax Wellstat Pac
fda sheet
Zovirax Wellstat Pac
msds (material safety sheet)
Zovirax Wellstat Pac
Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
Zovirax Wellstat Pac
Molecular Weight
225.205 g/mol
Zovirax Wellstat Pac
Melting Point
256.5 - 257 oC
Zovirax Wellstat Pac
H2O Solubility
3.399 mg/L
Zovirax Wellstat Pac
State
Solid
Zovirax Wellstat Pac
LogP
-1.314
Zovirax Wellstat Pac
Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
Zovirax Wellstat Pac
Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Zovirax Wellstat Pac
Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Zovirax Wellstat Pac
Absorption
Oral: bioavailability 10 to 20%
Zovirax Wellstat Pac
side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
Zovirax Wellstat Pac
Patient Information
Zovirax Wellstat Pac
Organisms Affected
Human herpes virus