Acycloguanosine
Acycloguanosine Brand names, Acycloguanosine Analogs
Acycloguanosine Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
Acycloguanosine Chemical_Formula
C8H11N5O3
Acycloguanosine RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
Acycloguanosine fda sheet
Acycloguanosine msds (material safety sheet)
Acycloguanosine Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
Acycloguanosine Molecular Weight
225.205 g/mol
Acycloguanosine Melting Point
256.5 - 257 oC
Acycloguanosine H2O Solubility
3.399 mg/L
Acycloguanosine State
Solid
Acycloguanosine LogP
-1.314
Acycloguanosine Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
Acycloguanosine Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Acycloguanosine Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Acycloguanosine Absorption
Oral: bioavailability 10 to 20%
Acycloguanosine side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
Acycloguanosine Patient Information
Acycloguanosine Organisms Affected
Human herpes virus
