Zovirax Zostab Pac
Brand names,
Zovirax Zostab Pac
Analogs
Zovirax Zostab Pac
Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
Zovirax Zostab Pac
Chemical_Formula
C8H11N5O3
Zovirax Zostab Pac
RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
Zovirax Zostab Pac
fda sheet
Zovirax Zostab Pac
msds (material safety sheet)
Zovirax Zostab Pac
Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
Zovirax Zostab Pac
Molecular Weight
225.205 g/mol
Zovirax Zostab Pac
Melting Point
256.5 - 257 oC
Zovirax Zostab Pac
H2O Solubility
3.399 mg/L
Zovirax Zostab Pac
State
Solid
Zovirax Zostab Pac
LogP
-1.314
Zovirax Zostab Pac
Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
Zovirax Zostab Pac
Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Zovirax Zostab Pac
Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Zovirax Zostab Pac
Absorption
Oral: bioavailability 10 to 20%
Zovirax Zostab Pac
side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
Zovirax Zostab Pac
Patient Information
Zovirax Zostab Pac
Organisms Affected
Human herpes virus