Vinkristin
Vinkristin Brand names, Vinkristin Analogs
- 22-Oxovincaleukoblastine
- Indole alkaloid
- LCR
- Leurocristine
- Onco TCS
- Oncovin
- Oncovin (1:1 sulfate salt)
- VCR
- VIN
- Vincaleukoblastine, 22-oxo-
- Vincasar (1:1 sulfate salt)
- Vincasar PFS
- Vincrex
- Vincrex (1:1 sulfate salt)
- Vincristina [DCIT]
- Vincristine Sulfate
- Vincristine Sulfate PFS
- Vincristinum [INN-Latin]
- Vincrstine
- Vincrystine
- Vinkristin
- Z-D-Val-Lys(Z)-OH
Vinkristin Brand Names Mixture
- No information avaliable
Vinkristin Chemical_Formula
C46H56N4O10
Vinkristin RX_link
http://www.rxlist.com/cgi/generic3/vincristine.htm
Vinkristin fda sheet
Vinkristin msds (material safety sheet)
Vinkristin Synthesis Reference
No information avaliable
Vinkristin Molecular Weight
824.958 g/mol
Vinkristin Melting Point
220 oC
Vinkristin H2O Solubility
No information avaliable
Vinkristin State
Solid
Vinkristin LogP
4.918
Vinkristin Dosage Forms
Liquid; Solution
Vinkristin Indication
For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis
Vinkristin Pharmacology
Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vinkristin Absorption
No information avaliable
Vinkristin side effects and Toxicity
IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg
Vinkristin Patient Information
PATIENT INFORMATION
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Vinkristin Organisms Affected
Humans and other mammals
