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Vincrstine Brand names, Vincrstine Analogs

Vincrstine Brand Names Mixture

  • No information avaliable

Vincrstine Chemical_Formula

C46H56N4O10

Vincrstine RX_link

http://www.rxlist.com/cgi/generic3/vincristine.htm

Vincrstine fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=35

Vincrstine msds (material safety sheet)

Vincrstine MSDS

Vincrstine Synthesis Reference

No information avaliable

Vincrstine Molecular Weight

824.958 g/mol

Vincrstine Melting Point

220 oC

Vincrstine H2O Solubility

No information avaliable

Vincrstine State

Solid

Vincrstine LogP

4.918

Vincrstine Dosage Forms

Liquid; Solution

Vincrstine Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

Vincrstine Pharmacology

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Vincrstine Absorption

No information avaliable

Vincrstine side effects and Toxicity

IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg

Vincrstine Patient Information

PATIENT INFORMATION

Follow the links

http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm

http://www.drugs.com/cons/Vincristine.html

Vincrstine Organisms Affected

Humans and other mammals