PharmacyCodes



Oncovin en es it fr

Oncovin Brand names, Oncovin Analogs

Oncovin Brand Names Mixture

  • No information avaliable

Oncovin Chemical_Formula

C46H56N4O10

Oncovin RX_link

http://www.rxlist.com/cgi/generic3/vincristine.htm

Oncovin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=35

Oncovin msds (material safety sheet)

Oncovin MSDS

Oncovin Synthesis Reference

No information avaliable

Oncovin Molecular Weight

824.958 g/mol

Oncovin Melting Point

220 oC

Oncovin H2O Solubility

No information avaliable

Oncovin State

Solid

Oncovin LogP

4.918

Oncovin Dosage Forms

Liquid; Solution

Oncovin Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

Oncovin Pharmacology

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Oncovin Absorption

No information avaliable

Oncovin side effects and Toxicity

IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg

Oncovin Patient Information

PATIENT INFORMATION

Follow the links

http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm

http://www.drugs.com/cons/Vincristine.html

Oncovin Organisms Affected

Humans and other mammals