PharmacyCodes



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VCR Brand names, VCR Analogs

VCR Brand Names Mixture

  • No information avaliable

VCR Chemical_Formula

C46H56N4O10

VCR RX_link

http://www.rxlist.com/cgi/generic3/vincristine.htm

VCR fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=35

VCR msds (material safety sheet)

VCR MSDS

VCR Synthesis Reference

No information avaliable

VCR Molecular Weight

824.958 g/mol

VCR Melting Point

220 oC

VCR H2O Solubility

No information avaliable

VCR State

Solid

VCR LogP

4.918

VCR Dosage Forms

Liquid; Solution

VCR Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

VCR Pharmacology

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

VCR Absorption

No information avaliable

VCR side effects and Toxicity

IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg

VCR Patient Information

PATIENT INFORMATION

Follow the links

http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm

http://www.drugs.com/cons/Vincristine.html

VCR Organisms Affected

Humans and other mammals