VIN
VIN Brand names, VIN Analogs
VIN Brand Names Mixture
- No information avaliable
VIN Chemical_Formula
C45H54N4O8
VIN RX_link
http://www.rxlist.com/cgi/generic2/vinor.htm
VIN fda sheet
VIN msds (material safety sheet)
VIN Synthesis Reference
No information avaliable
VIN Molecular Weight
778.932 g/mol
VIN Melting Point
No information avaliable
VIN H2O Solubility
No information avaliable
VIN State
Solid
VIN LogP
5.829
VIN Dosage Forms
Solution
VIN Indication
For the treatment of non-small-cell lung carcinoma
VIN Pharmacology
Vinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
VIN Absorption
No information avaliable
VIN side effects and Toxicity
No information avaliable
VIN Patient Information
No information avaliable
VIN Organisms Affected
Humans and other mammals
