Vincrystine
Vincrystine Brand names, Vincrystine Analogs
- 22-Oxovincaleukoblastine
- Indole alkaloid
- LCR
- Leurocristine
- Onco TCS
- Oncovin
- Oncovin (1:1 sulfate salt)
- VCR
- VIN
- Vincaleukoblastine, 22-oxo-
- Vincasar (1:1 sulfate salt)
- Vincasar PFS
- Vincrex
- Vincrex (1:1 sulfate salt)
- Vincristina [DCIT]
- Vincristine Sulfate
- Vincristine Sulfate PFS
- Vincristinum [INN-Latin]
- Vincrstine
- Vincrystine
- Vinkristin
- Z-D-Val-Lys(Z)-OH
Vincrystine Brand Names Mixture
- No information avaliable
Vincrystine Chemical_Formula
C46H56N4O10
Vincrystine RX_link
http://www.rxlist.com/cgi/generic3/vincristine.htm
Vincrystine fda sheet
Vincrystine msds (material safety sheet)
Vincrystine Synthesis Reference
No information avaliable
Vincrystine Molecular Weight
824.958 g/mol
Vincrystine Melting Point
220 oC
Vincrystine H2O Solubility
No information avaliable
Vincrystine State
Solid
Vincrystine LogP
4.918
Vincrystine Dosage Forms
Liquid; Solution
Vincrystine Indication
For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis
Vincrystine Pharmacology
Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vincrystine Absorption
No information avaliable
Vincrystine side effects and Toxicity
IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg
Vincrystine Patient Information
PATIENT INFORMATION
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Vincrystine Organisms Affected
Humans and other mammals
