Indole alkaloid
Indole alkaloid Brand names, Indole alkaloid Analogs
- 22-Oxovincaleukoblastine
- Indole alkaloid
- LCR
- Leurocristine
- Onco TCS
- Oncovin
- Oncovin (1:1 sulfate salt)
- VCR
- VIN
- Vincaleukoblastine, 22-oxo-
- Vincasar (1:1 sulfate salt)
- Vincasar PFS
- Vincrex
- Vincrex (1:1 sulfate salt)
- Vincristina [DCIT]
- Vincristine Sulfate
- Vincristine Sulfate PFS
- Vincristinum [INN-Latin]
- Vincrstine
- Vincrystine
- Vinkristin
- Z-D-Val-Lys(Z)-OH
Indole alkaloid Brand Names Mixture
- No information avaliable
Indole alkaloid Chemical_Formula
C46H56N4O10
Indole alkaloid RX_link
http://www.rxlist.com/cgi/generic3/vincristine.htm
Indole alkaloid fda sheet
Indole alkaloid msds (material safety sheet)
Indole alkaloid Synthesis Reference
No information avaliable
Indole alkaloid Molecular Weight
824.958 g/mol
Indole alkaloid Melting Point
220 oC
Indole alkaloid H2O Solubility
No information avaliable
Indole alkaloid State
Solid
Indole alkaloid LogP
4.918
Indole alkaloid Dosage Forms
Liquid; Solution
Indole alkaloid Indication
For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis
Indole alkaloid Pharmacology
Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Indole alkaloid Absorption
No information avaliable
Indole alkaloid side effects and Toxicity
IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg
Indole alkaloid Patient Information
PATIENT INFORMATION
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Indole alkaloid Organisms Affected
Humans and other mammals
