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Indole alkaloid Brand names, Indole alkaloid Analogs

Indole alkaloid Brand Names Mixture

  • No information avaliable

Indole alkaloid Chemical_Formula


Indole alkaloid RX_link

Indole alkaloid fda sheet

Indole alkaloid msds (material safety sheet)

Indole_alkaloid MSDS

Indole alkaloid Synthesis Reference

No information avaliable

Indole alkaloid Molecular Weight

824.958 g/mol

Indole alkaloid Melting Point

220 oC

Indole alkaloid H2O Solubility

No information avaliable

Indole alkaloid State


Indole alkaloid LogP


Indole alkaloid Dosage Forms

Liquid; Solution

Indole alkaloid Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

Indole alkaloid Pharmacology

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Indole alkaloid Absorption

No information avaliable

Indole alkaloid side effects and Toxicity

IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg

Indole alkaloid Patient Information


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Indole alkaloid Organisms Affected

Humans and other mammals