Vincristine Sulfate PFS
Vincristine Sulfate PFS Brand names, Vincristine Sulfate PFS Analogs
- 22-Oxovincaleukoblastine
- Indole alkaloid
- LCR
- Leurocristine
- Onco TCS
- Oncovin
- Oncovin (1:1 sulfate salt)
- VCR
- VIN
- Vincaleukoblastine, 22-oxo-
- Vincasar (1:1 sulfate salt)
- Vincasar PFS
- Vincrex
- Vincrex (1:1 sulfate salt)
- Vincristina [DCIT]
- Vincristine Sulfate
- Vincristine Sulfate PFS
- Vincristinum [INN-Latin]
- Vincrstine
- Vincrystine
- Vinkristin
- Z-D-Val-Lys(Z)-OH
Vincristine Sulfate PFS Brand Names Mixture
- No information avaliable
Vincristine Sulfate PFS Chemical_Formula
C46H56N4O10
Vincristine Sulfate PFS RX_link
http://www.rxlist.com/cgi/generic3/vincristine.htm
Vincristine Sulfate PFS fda sheet
Vincristine Sulfate PFS msds (material safety sheet)
Vincristine Sulfate PFS Synthesis Reference
No information avaliable
Vincristine Sulfate PFS Molecular Weight
824.958 g/mol
Vincristine Sulfate PFS Melting Point
220 oC
Vincristine Sulfate PFS H2O Solubility
No information avaliable
Vincristine Sulfate PFS State
Solid
Vincristine Sulfate PFS LogP
4.918
Vincristine Sulfate PFS Dosage Forms
Liquid; Solution
Vincristine Sulfate PFS Indication
For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis
Vincristine Sulfate PFS Pharmacology
Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vincristine Sulfate PFS Absorption
No information avaliable
Vincristine Sulfate PFS side effects and Toxicity
IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg
Vincristine Sulfate PFS Patient Information
PATIENT INFORMATION
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Vincristine Sulfate PFS Organisms Affected
Humans and other mammals
