Vincasar PFS
Vincasar PFS Brand names, Vincasar PFS Analogs
- 22-Oxovincaleukoblastine
- Indole alkaloid
- LCR
- Leurocristine
- Onco TCS
- Oncovin
- Oncovin (1:1 sulfate salt)
- VCR
- VIN
- Vincaleukoblastine, 22-oxo-
- Vincasar (1:1 sulfate salt)
- Vincasar PFS
- Vincrex
- Vincrex (1:1 sulfate salt)
- Vincristina [DCIT]
- Vincristine Sulfate
- Vincristine Sulfate PFS
- Vincristinum [INN-Latin]
- Vincrstine
- Vincrystine
- Vinkristin
- Z-D-Val-Lys(Z)-OH
Vincasar PFS Brand Names Mixture
- No information avaliable
Vincasar PFS Chemical_Formula
C46H56N4O10
Vincasar PFS RX_link
http://www.rxlist.com/cgi/generic3/vincristine.htm
Vincasar PFS fda sheet
Vincasar PFS msds (material safety sheet)
Vincasar PFS Synthesis Reference
No information avaliable
Vincasar PFS Molecular Weight
824.958 g/mol
Vincasar PFS Melting Point
220 oC
Vincasar PFS H2O Solubility
No information avaliable
Vincasar PFS State
Solid
Vincasar PFS LogP
4.918
Vincasar PFS Dosage Forms
Liquid; Solution
Vincasar PFS Indication
For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis
Vincasar PFS Pharmacology
Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vincasar PFS Absorption
No information avaliable
Vincasar PFS side effects and Toxicity
IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg
Vincasar PFS Patient Information
PATIENT INFORMATION
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Follow the links
http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm
http://www.drugs.com/cons/Vincristine.html
Vincasar PFS Organisms Affected
Humans and other mammals
