22-Oxovincaleukoblastine en es it fr

22-Oxovincaleukoblastine Brand names, 22-Oxovincaleukoblastine Analogs

22-Oxovincaleukoblastine Brand Names Mixture

  • No information avaliable

22-Oxovincaleukoblastine Chemical_Formula


22-Oxovincaleukoblastine RX_link


22-Oxovincaleukoblastine fda sheet


22-Oxovincaleukoblastine msds (material safety sheet)

22-Oxovincaleukoblastine MSDS

22-Oxovincaleukoblastine Synthesis Reference

No information avaliable

22-Oxovincaleukoblastine Molecular Weight

824.958 g/mol

22-Oxovincaleukoblastine Melting Point

220 oC

22-Oxovincaleukoblastine H2O Solubility

No information avaliable

22-Oxovincaleukoblastine State


22-Oxovincaleukoblastine LogP


22-Oxovincaleukoblastine Dosage Forms

Liquid; Solution

22-Oxovincaleukoblastine Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

22-Oxovincaleukoblastine Pharmacology

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

22-Oxovincaleukoblastine Absorption

No information avaliable

22-Oxovincaleukoblastine side effects and Toxicity

IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg

22-Oxovincaleukoblastine Patient Information


Follow the links



22-Oxovincaleukoblastine Organisms Affected

Humans and other mammals