Onco TCS en es it fr

Onco TCS Brand names, Onco TCS Analogs

Onco TCS Brand Names Mixture

  • No information avaliable

Onco TCS Chemical_Formula

C46H56N4O10

Onco TCS RX_link

http://www.rxlist.com/cgi/generic3/vincristine.htm

Onco TCS fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=35

Onco TCS msds (material safety sheet)

Onco_TCS MSDS

Onco TCS Synthesis Reference

No information avaliable

Onco TCS Molecular Weight

824.958 g/mol

Onco TCS Melting Point

220 oC

Onco TCS H2O Solubility

No information avaliable

Onco TCS State

Solid

Onco TCS LogP

4.918

Onco TCS Dosage Forms

Liquid; Solution

Onco TCS Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

Onco TCS Pharmacology

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Onco TCS Absorption

No information avaliable

Onco TCS side effects and Toxicity

IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg

Onco TCS Patient Information

PATIENT INFORMATION

Follow the links

http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm

http://www.drugs.com/cons/Vincristine.html

Onco TCS Organisms Affected

Humans and other mammals