PharmacyCodes



Vincrex en es it fr

Vincrex Brand names, Vincrex Analogs

Vincrex Brand Names Mixture

  • No information avaliable

Vincrex Chemical_Formula

C46H56N4O10

Vincrex RX_link

http://www.rxlist.com/cgi/generic3/vincristine.htm

Vincrex fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=35

Vincrex msds (material safety sheet)

Vincrex MSDS

Vincrex Synthesis Reference

No information avaliable

Vincrex Molecular Weight

824.958 g/mol

Vincrex Melting Point

220 oC

Vincrex H2O Solubility

No information avaliable

Vincrex State

Solid

Vincrex LogP

4.918

Vincrex Dosage Forms

Liquid; Solution

Vincrex Indication

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

Vincrex Pharmacology

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Vincrex Absorption

No information avaliable

Vincrex side effects and Toxicity

IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg

Vincrex Patient Information

PATIENT INFORMATION

Follow the links

http://www.rxlist.com/cgi/generic3/vincristine_wcp.htm

http://www.drugs.com/cons/Vincristine.html

Vincrex Organisms Affected

Humans and other mammals