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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H25N5O4
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RX_link
http://www.rxlist.com/cgi/generic/teraz.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
M. Winn et al., U.S. Pat. 4,026,894 (1977)
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Molecular Weight
387.433 g/mol
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Melting Point
273 oC
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H2O Solubility
29.7mg/mL
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State
Solid
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LogP
0.875
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Dosage Forms
Tablet
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Indication
For the treatment of symptomatic benign prostatic hyperplasia (BPH) and also for hypertension.
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Pharmacology
Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an alpha-adrenergic blocking agent, terazosin is used to treat hypertension and benign prostatic hypertrophy (BPH). Terazosin produces vasodilation and reduces peripheral resistance but in general has slight effect on cardiac output. Antihypertensive effect with chronic dosing is usually not accompanied by reflex tachycardia.
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Absorption
Essentially completely absorbed in man (90% bioavailability).
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side effects and Toxicity
LD50=259.3mg/kg (i.v. in mice)
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Patient Information
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Organisms Affected
Humans and other mammals