Terazosina [Inn-Spanish]
Brand names,
Terazosina [Inn-Spanish]
Analogs
Terazosina [Inn-Spanish]
Brand Names Mixture
Terazosina [Inn-Spanish]
Chemical_Formula
C19H25N5O4
Terazosina [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic/teraz.htm
Terazosina [Inn-Spanish]
fda sheet
Terazosina [Inn-Spanish]
msds (material safety sheet)
Terazosina [Inn-Spanish]
Synthesis Reference
M. Winn et al., U.S. Pat. 4,026,894 (1977)
Terazosina [Inn-Spanish]
Molecular Weight
387.433 g/mol
Terazosina [Inn-Spanish]
Melting Point
273 oC
Terazosina [Inn-Spanish]
H2O Solubility
29.7mg/mL
Terazosina [Inn-Spanish]
State
Solid
Terazosina [Inn-Spanish]
LogP
0.875
Terazosina [Inn-Spanish]
Dosage Forms
Tablet
Terazosina [Inn-Spanish]
Indication
For the treatment of symptomatic benign prostatic hyperplasia (BPH) and also for hypertension.
Terazosina [Inn-Spanish]
Pharmacology
Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an alpha-adrenergic blocking agent, terazosin is used to treat hypertension and benign prostatic hypertrophy (BPH). Terazosin produces vasodilation and reduces peripheral resistance but in general has slight effect on cardiac output. Antihypertensive effect with chronic dosing is usually not accompanied by reflex tachycardia.
Terazosina [Inn-Spanish]
Absorption
Essentially completely absorbed in man (90% bioavailability).
Terazosina [Inn-Spanish]
side effects and Toxicity
LD50=259.3mg/kg (i.v. in mice)
Terazosina [Inn-Spanish]
Patient Information
Terazosina [Inn-Spanish]
Organisms Affected
Humans and other mammals