Fosfomic
Fosfomic Brand names, Fosfomic Analogs
Fosfomic Brand Names Mixture
- No information avaliable
Fosfomic Chemical_Formula
C19H25N5O4
Fosfomic RX_link
http://www.rxlist.com/cgi/generic/teraz.htm
Fosfomic fda sheet
Fosfomic msds (material safety sheet)
Fosfomic Synthesis Reference
M. Winn et al., U.S. Pat. 4,026,894 (1977)
Fosfomic Molecular Weight
387.433 g/mol
Fosfomic Melting Point
273 oC
Fosfomic H2O Solubility
29.7mg/mL
Fosfomic State
Solid
Fosfomic LogP
0.875
Fosfomic Dosage Forms
Tablet
Fosfomic Indication
For the treatment of symptomatic benign prostatic hyperplasia (BPH) and also for hypertension.
Fosfomic Pharmacology
Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an alpha-adrenergic blocking agent, terazosin is used to treat hypertension and benign prostatic hypertrophy (BPH). Terazosin produces vasodilation and reduces peripheral resistance but in general has slight effect on cardiac output. Antihypertensive effect with chronic dosing is usually not accompanied by reflex tachycardia.
Fosfomic Absorption
Essentially completely absorbed in man (90% bioavailability).
Fosfomic side effects and Toxicity
LD50=259.3mg/kg (i.v. in mice)
Fosfomic Patient Information
Fosfomic Organisms Affected
Humans and other mammals
