Terazosine
Terazosine Brand names, Terazosine Analogs
Terazosine Brand Names Mixture
- No information avaliable
Terazosine Chemical_Formula
C19H25N5O4
Terazosine RX_link
http://www.rxlist.com/cgi/generic/teraz.htm
Terazosine fda sheet
Terazosine msds (material safety sheet)
Terazosine Synthesis Reference
M. Winn et al., U.S. Pat. 4,026,894 (1977)
Terazosine Molecular Weight
387.433 g/mol
Terazosine Melting Point
273 oC
Terazosine H2O Solubility
29.7mg/mL
Terazosine State
Solid
Terazosine LogP
0.875
Terazosine Dosage Forms
Tablet
Terazosine Indication
For the treatment of symptomatic benign prostatic hyperplasia (BPH) and also for hypertension.
Terazosine Pharmacology
Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an alpha-adrenergic blocking agent, terazosin is used to treat hypertension and benign prostatic hypertrophy (BPH). Terazosin produces vasodilation and reduces peripheral resistance but in general has slight effect on cardiac output. Antihypertensive effect with chronic dosing is usually not accompanied by reflex tachycardia.
Terazosine Absorption
Essentially completely absorbed in man (90% bioavailability).
Terazosine side effects and Toxicity
LD50=259.3mg/kg (i.v. in mice)
Terazosine Patient Information
Terazosine Organisms Affected
Humans and other mammals
