Totacillin-N
Brand names,
Totacillin-N
Analogs
Totacillin-N
Brand Names Mixture
- Pro Biosan Kit (Ampicillin + Probenecid)
- Synergistin Injectable Suspension (Ampicillin + Sulbactam (Sulbactam Benzathine))
Totacillin-N
Chemical_Formula
C16H19N3O4S
Totacillin-N
RX_link
http://www.rxlist.com/cgi/generic/ampicillin.htm
Totacillin-N
fda sheet
Totacillin-N
msds (material safety sheet)
Totacillin-N
Synthesis Reference
No information avaliable
Totacillin-N
Molecular Weight
349.406 g/mol
Totacillin-N
Melting Point
208 oC
Totacillin-N
H2O Solubility
1.01E+004 mg/L
Totacillin-N
State
Solid
Totacillin-N
LogP
1.35
Totacillin-N
Dosage Forms
Powder for solution
Totacillin-N
Indication
For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
Totacillin-N
Pharmacology
Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Totacillin-N
Absorption
No information avaliable
Totacillin-N
side effects and Toxicity
No information avaliable
Totacillin-N
Patient Information
1. The patient should inform the physician of any history of sensitivity to allergens, including previous
hypersensitivity reactions to penicillins and cephalosporins.
2. The patient should discontinue ampicillin and contact the physician immediately if any side effect occurs.
3. Ampicillin should be taken with a full glass (8 oz) of water, one-half hour before or two hours after
meals.
4. Diabetic patients should consult with the physician before changing diet or dosage of diabetes medication .
Totacillin-N
Organisms Affected
Enteric bacteria and other eubacteria