Totapen
Brand names,
Totapen
Analogs
Totapen
Brand Names Mixture
- Pro Biosan Kit (Ampicillin + Probenecid)
- Synergistin Injectable Suspension (Ampicillin + Sulbactam (Sulbactam Benzathine))
Totapen
Chemical_Formula
C16H19N3O4S
Totapen
RX_link
http://www.rxlist.com/cgi/generic/ampicillin.htm
Totapen
fda sheet
Totapen
msds (material safety sheet)
Totapen
Synthesis Reference
No information avaliable
Totapen
Molecular Weight
349.406 g/mol
Totapen
Melting Point
208 oC
Totapen
H2O Solubility
1.01E+004 mg/L
Totapen
State
Solid
Totapen
LogP
1.35
Totapen
Dosage Forms
Powder for solution
Totapen
Indication
For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
Totapen
Pharmacology
Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Totapen
Absorption
No information avaliable
Totapen
side effects and Toxicity
No information avaliable
Totapen
Patient Information
1. The patient should inform the physician of any history of sensitivity to allergens, including previous
hypersensitivity reactions to penicillins and cephalosporins.
2. The patient should discontinue ampicillin and contact the physician immediately if any side effect occurs.
3. Ampicillin should be taken with a full glass (8 oz) of water, one-half hour before or two hours after
meals.
4. Diabetic patients should consult with the physician before changing diet or dosage of diabetes medication .
Totapen
Organisms Affected
Enteric bacteria and other eubacteria