Topsym
Brand names,
Topsym
Analogs
Topsym
Brand Names Mixture
- Rifater - Tab (Isoniazid + Pyrazinamide + Rifampin)
Topsym
Chemical_Formula
C2H6OS
Topsym
RX_link
http://www.rxlist.com/cgi/generic2/dmso.htm
Topsym
fda sheet
Topsym
msds (material safety sheet)
Topsym
Synthesis Reference
No information avaliable
Topsym
Molecular Weight
78.1344 g/mol
Topsym
Melting Point
18.5 oC
Topsym
H2O Solubility
1E+006 mg/L
Topsym
State
Liquid
Topsym
LogP
-1.082
Topsym
Dosage Forms
Cream (70%); Gel (70%, 90%); Injection (50%, 100%); Liquid (99%, 90%, 70%); Solution (50%)
Topsym
Indication
For the symptomatic relief of patients with interstitial cystitis.
Topsym
Pharmacology
Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substances through the skin. For this reason, mixtures of idoxuridine and dimethyl sulfoxide have been used for topical treatment of herpes zoster in the United Kingdom.
Topsym
Absorption
Readily and rapidly absorbed following administration by all routes and distributed throughout the body.
Topsym
side effects and Toxicity
The oral LD50 of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient.
Topsym
Patient Information
Topsym
Organisms Affected
Humans and other mammals