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Brand names,
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Analogs
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Brand Names Mixture
- Rifater - Tab (Isoniazid + Pyrazinamide + Rifampin)
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Chemical_Formula
C2H6OS
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RX_link
http://www.rxlist.com/cgi/generic2/dmso.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
78.1344 g/mol
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Melting Point
18.5 oC
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H2O Solubility
1E+006 mg/L
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State
Liquid
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LogP
-1.082
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Dosage Forms
Cream (70%); Gel (70%, 90%); Injection (50%, 100%); Liquid (99%, 90%, 70%); Solution (50%)
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Indication
For the symptomatic relief of patients with interstitial cystitis.
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Pharmacology
Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substances through the skin. For this reason, mixtures of idoxuridine and dimethyl sulfoxide have been used for topical treatment of herpes zoster in the United Kingdom.
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Absorption
Readily and rapidly absorbed following administration by all routes and distributed throughout the body.
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side effects and Toxicity
The oral LD50 of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient.
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Patient Information
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Organisms Affected
Humans and other mammals