Sulfapyridine
Brand names,
Sulfapyridine
Analogs
Sulfapyridine
Brand Names Mixture
- Foot Rot Boluses (Ethylenediamine Dihydroiodide + Sulfapyridine)
- Neutral Sulfa 50 (Sulfamethazine + Sulfapyridine + Sulfathiazole)
- Neutral Sulfa 7 (Sulfamethazine + Sulfapyridine + Sulfathiazole)
- Trisulfa G Liq (Sulfamethazine + Sulfapyridine + Sulfathiazole)
Sulfapyridine
Chemical_Formula
C11H11N3O2S
Sulfapyridine
RX_link
No information avaliable
Sulfapyridine
fda sheet
Sulfapyridine
msds (material safety sheet)
Sulfapyridine
Synthesis Reference
No information avaliable
Sulfapyridine
Molecular Weight
249.29 g/mol
Sulfapyridine
Melting Point
192 oC
Sulfapyridine
H2O Solubility
268 mg/L
Sulfapyridine
State
Solid
Sulfapyridine
LogP
2.384
Sulfapyridine
Dosage Forms
Tablet
Sulfapyridine
Indication
For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum
Sulfapyridine
Pharmacology
Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfapyridine
Absorption
approximately 60-80%
Sulfapyridine
side effects and Toxicity
ORL-RAT 15800 mg/Kg
Sulfapyridine
Patient Information
PATIENT INFORMATION
Follow the links
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202536.html
http://www.drugs.com/cons/Sulfapyridine.html
Sulfapyridine
Organisms Affected
Humans and other mammals