Sulfidine
Brand names,
Sulfidine
Analogs
Sulfidine
Brand Names Mixture
- Foot Rot Boluses (Ethylenediamine Dihydroiodide + Sulfapyridine)
- Neutral Sulfa 50 (Sulfamethazine + Sulfapyridine + Sulfathiazole)
- Neutral Sulfa 7 (Sulfamethazine + Sulfapyridine + Sulfathiazole)
- Trisulfa G Liq (Sulfamethazine + Sulfapyridine + Sulfathiazole)
Sulfidine
Chemical_Formula
C11H11N3O2S
Sulfidine
RX_link
No information avaliable
Sulfidine
fda sheet
Sulfidine
msds (material safety sheet)
Sulfidine
Synthesis Reference
No information avaliable
Sulfidine
Molecular Weight
249.29 g/mol
Sulfidine
Melting Point
192 oC
Sulfidine
H2O Solubility
268 mg/L
Sulfidine
State
Solid
Sulfidine
LogP
2.384
Sulfidine
Dosage Forms
Tablet
Sulfidine
Indication
For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum
Sulfidine
Pharmacology
Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfidine
Absorption
approximately 60-80%
Sulfidine
side effects and Toxicity
ORL-RAT 15800 mg/Kg
Sulfidine
Patient Information
PATIENT INFORMATION
Follow the links
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202536.html
http://www.drugs.com/cons/Sulfapyridine.html
Sulfidine
Organisms Affected
Humans and other mammals