Pyriamid
Brand names,
Pyriamid
Analogs
Pyriamid
Brand Names Mixture
- Foot Rot Boluses (Ethylenediamine Dihydroiodide + Sulfapyridine)
- Neutral Sulfa 50 (Sulfamethazine + Sulfapyridine + Sulfathiazole)
- Neutral Sulfa 7 (Sulfamethazine + Sulfapyridine + Sulfathiazole)
- Trisulfa G Liq (Sulfamethazine + Sulfapyridine + Sulfathiazole)
Pyriamid
Chemical_Formula
C11H11N3O2S
Pyriamid
RX_link
No information avaliable
Pyriamid
fda sheet
Pyriamid
msds (material safety sheet)
Pyriamid
Synthesis Reference
No information avaliable
Pyriamid
Molecular Weight
249.29 g/mol
Pyriamid
Melting Point
192 oC
Pyriamid
H2O Solubility
268 mg/L
Pyriamid
State
Solid
Pyriamid
LogP
2.384
Pyriamid
Dosage Forms
Tablet
Pyriamid
Indication
For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum
Pyriamid
Pharmacology
Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Pyriamid
Absorption
approximately 60-80%
Pyriamid
side effects and Toxicity
ORL-RAT 15800 mg/Kg
Pyriamid
Patient Information
PATIENT INFORMATION
Follow the links
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202536.html
http://www.drugs.com/cons/Sulfapyridine.html
Pyriamid
Organisms Affected
Humans and other mammals