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Splendil Brand names, Splendil Analogs

Splendil Brand Names Mixture

  • No information avaliable

Splendil Chemical_Formula


Splendil RX_link


Splendil fda sheet

Splendil FDA

Splendil msds (material safety sheet)

Splendil Synthesis Reference

P. B. Berntsson et al., U.S. Pat. 4,264,611 (1980)

Splendil Molecular Weight

384.253 g/mol

Splendil Melting Point


Splendil H2O Solubility

19.7 mg/L

Splendil State


Splendil LogP


Splendil Dosage Forms

Oral tablets

Splendil Indication

For the treatment of hypertension

Splendil Pharmacology

Felodipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Felodipine is similar to other peripheral vasodilators. Felodipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes blocking the calcium channels. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Splendil Absorption


Splendil side effects and Toxicity

excessive peripheral vasodilation with marked hypotension and possibly bradycardia

Splendil Patient Information

Information for the Patient

Patients should be instructed to take felodipine whole and not to crush or chew the
tablets. They should be told that mild gingival hyperplasia (gum swelling) has been
reported. Good dental hygiene decreases its incidence and severity.

Note: As with many other drugs, certain advice to patients being treated with felodipine
is warranted. This information is intended to aid in the safe and effective use of this
medication. It is not a disclosure of all possible adverse or intended effects.

Splendil Organisms Affected

Humans and other mammals