Splendil
Splendil Brand names, Splendil Analogs
- AGON SR
- Agon
- Dl-Felodipine
- FEXOFENADINE HCL
- Faropenem
- Feloday
- Felodipina [Inn-Spanish]
- Felodipine [Usan:Ban:Inn]
- Felodipinum [Inn-Latin]
- Felodur Er
- Felogard
- Fexofenadine Hydrochloride
- Fexofinadine Hcl
- Flodil
- Hydac
- Lexxel
- Modip
- Munobal
- Munobal Retard
- Penedil
- Perfudal
- Plandil
- Plendil
- Plendil Depottab
- Plendil Er
- Plendil Retard
- Preslow
- Prevex
- Renedil
- Splendil
Splendil Brand Names Mixture
- No information avaliable
Splendil Chemical_Formula
C18H19Cl2NO4
Splendil RX_link
http://www.rxlist.com/cgi/generic2/felo.htm
Splendil fda sheet
Splendil msds (material safety sheet)
Splendil Synthesis Reference
P. B. Berntsson et al., U.S. Pat. 4,264,611 (1980)
Splendil Molecular Weight
384.253 g/mol
Splendil Melting Point
145oC
Splendil H2O Solubility
19.7 mg/L
Splendil State
Solid
Splendil LogP
4.121
Splendil Dosage Forms
Oral tablets
Splendil Indication
For the treatment of hypertension
Splendil Pharmacology
Felodipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Felodipine is similar to other peripheral vasodilators. Felodipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes blocking the calcium channels. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Splendil Absorption
15%
Splendil side effects and Toxicity
excessive peripheral vasodilation with marked hypotension and possibly bradycardia
Splendil Patient Information
Information for the Patient
Patients should be instructed to take felodipine whole and not to crush or chew the
tablets. They should be told that mild gingival hyperplasia (gum swelling) has been
reported. Good dental hygiene decreases its incidence and severity.
Note: As with many other drugs, certain advice to patients being treated with felodipine
is warranted. This information is intended to aid in the safe and effective use of this
medication. It is not a disclosure of all possible adverse or intended effects.
Patients should be instructed to take felodipine whole and not to crush or chew the
tablets. They should be told that mild gingival hyperplasia (gum swelling) has been
reported. Good dental hygiene decreases its incidence and severity.
Note: As with many other drugs, certain advice to patients being treated with felodipine
is warranted. This information is intended to aid in the safe and effective use of this
medication. It is not a disclosure of all possible adverse or intended effects.
Splendil Organisms Affected
Humans and other mammals
